Patrick M Woster Selected Research

Polyamine Oxidase

1/2020	Spermine oxidase mediates Helicobacter pylori-induced gastric inflammation, DNA damage, and carcinogenic signaling.
10/2010	Spermine oxidase (SMO) activity in breast tumor tissues and biochemical analysis of the anticancer spermine analogues BENSpm and CPENSpm.
10/2009	A small molecule polyamine oxidase inhibitor blocks androgen-induced oxidative stress and delays prostate cancer progression in the transgenic adenocarcinoma of the mouse prostate model.
11/2007	Studies of the mechanism by which increased spermidine/spermine N1-acetyltransferase activity increases susceptibility to skin carcinogenesis.
12/2005	Spermine oxidase SMO(PAOh1), Not N1-acetylpolyamine oxidase PAO, is the primary source of cytotoxic H2O2 in polyamine analogue-treated human breast cancer cell lines.
11/2003	Induction of the PAOh1/SMO polyamine oxidase by polyamine analogues in human lung carcinoma cells.

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Patrick M Woster Research Topics

Disease

31	Neoplasms (Cancer) 12/2022 - 05/2002
6	Carcinogenesis 01/2020 - 05/2007
6	Breast Neoplasms (Breast Cancer) 01/2018 - 09/2005
5	Carcinoma (Carcinomatosis) 01/2018 - 11/2003
3	Malaria 11/2022 - 05/2010
3	Inflammation (Inflammations) 01/2020 - 09/2011
3	Leukemia 01/2018 - 10/2005
2	Neuroblastoma 12/2022 - 01/2022
2	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2022 - 03/2014
2	HIV Infections (HIV Infection) 12/2013 - 02/2006
2	Colonic Neoplasms (Colon Cancer) 01/2013 - 05/2007
2	Lung Neoplasms (Lung Cancer) 02/2012 - 08/2002
1	Alcoholic Liver Diseases (Alcoholic Liver Disease) 11/2022
1	Sickle Cell Anemia (Hemoglobin S Disease) 06/2020
1	Stomach Neoplasms (Stomach Cancer) 01/2020
1	Infarction (Infarctions) 12/2019
1	Fibrosis (Cirrhosis) 12/2019
1	Necrosis 12/2019
1	Gastrointestinal Neoplasms (Gastrointestinal Cancer) 01/2018
1	Periodontal Diseases (Periodontal Disease) 01/2018
1	Kidney Neoplasms (Kidney Cancer) 01/2018
1	Glucose Intolerance 04/2015
1	Hematologic Neoplasms (Hematological Malignancy) 03/2014
1	Skin Neoplasms (Skin Cancer) 02/2013
1	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 02/2012
1	Colitis 09/2011

Drug/Important Bio-Agent (IBA)

25	PolyaminesIBA 01/2022 - 05/2002
10	EnzymesIBA 03/2018 - 11/2003
8	Lysine (L-Lysine)FDA Link 03/2018 - 07/2010
6	Polyamine OxidaseIBA 01/2020 - 11/2003
6	Histones (Histone)IBA 04/2015 - 10/2005
6	ChromatinIBA 09/2012 - 05/2007
5	Oxidoreductases (Dehydrogenase)IBA 05/2019 - 07/2005
5	Ornithine Decarboxylase (Decarboxylase, Ornithine)IBA 01/2018 - 01/2005
5	N(1),N(11)-diethylnorspermineIBA 02/2012 - 08/2002
4	SpermineIBA 01/2020 - 11/2007
3	BiguanidesIBA 01/2022 - 07/2010
3	Reactive Oxygen Species (Oxygen Radicals)IBA 03/2014 - 11/2007
3	Histone Deacetylase InhibitorsIBA 01/2012 - 10/2005
2	Messenger RNA (mRNA)IBA 12/2022 - 12/2005
2	Transcription Factors (Transcription Factor)IBA 11/2022 - 05/2007
2	Eflornithine (Ornidyl)FDA Link 10/2021 - 11/2007
2	SpermidineIBA 01/2020 - 11/2007
2	AldehydesIBA 12/2019 - 11/2007
2	Urea (Carbamide)FDA LinkGeneric 04/2015 - 09/2012
2	ThioureaIBA 04/2015 - 09/2012
2	anthraceneIBA 03/2014 - 11/2007
2	DNA (Deoxyribonucleic Acid)IBA 01/2013 - 12/2009
2	MethyltransferasesIBA 01/2013 - 12/2009
2	GuanidinesIBA 09/2012 - 07/2010
2	Small Interfering RNA (siRNA)IBA 02/2012 - 12/2005
2	Histone Deacetylases (Histone Deacetylase)IBA 01/2012 - 01/2011
2	CytokinesIBA 08/2009 - 02/2006
1	Tranylcypromine (Parnate)FDA LinkGeneric 12/2022
1	Antimalarials (Antimalarial Agents)IBA 11/2022
1	Green Fluorescent ProteinsIBA 11/2022
1	Mitochondrial DNA (mtDNA)IBA 11/2022
1	Aldehyde DehydrogenaseIBA 11/2022
1	Alcohol Dehydrogenase (Alcohol Dehydrogenase (NAD+))IBA 11/2022
1	Lamin Type B (Lamin B)IBA 11/2022
1	AcetaldehydeIBA 11/2022
1	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA 11/2022
1	Malondialdehyde (Propanedial)IBA 11/2022
1	tetramethylrhodamine (T 489)IBA 11/2022
1	Lysosomal-Associated Membrane Protein 1IBA 11/2022
1	Voltage-Dependent Anion ChannelsIBA 11/2022
1	Propidium (Propidium Iodide)IBA 11/2022
1	Glyceraldehyde-3-Phosphate Dehydrogenases (GAPD)IBA 11/2022
1	PTEN-induced putative kinaseIBA 11/2022
1	rhodamine dextranIBA 11/2022
1	Tretinoin (Retinoic Acid)FDA LinkGeneric 01/2022
1	RetinoidsIBA 01/2022
1	Monoclonal AntibodiesIBA 10/2021
1	isatuximabIBA 10/2021
1	daratumumabIBA 10/2021
1	Fetal Hemoglobin (Hemoglobin F)IBA 06/2020
1	GlobinsIBA 06/2020
1	CateninsIBA 01/2020
1	salicylhydroxamic acid (SHAM)IBA 12/2019
1	C.I. direct red 80IBA 12/2019
1	CarcinogensIBA 01/2018
1	CurcuminIBA 01/2018
1	Glucose (Dextrose)FDA LinkGeneric 04/2015
1	diphenyl (biphenyl)IBA 03/2014
1	Cadherins (E-Cadherin)IBA 03/2014
1	afimoxifene (hydroxytamoxifen)IBA 03/2014
1	pol Gene ProductsIBA 12/2013
1	ornithine decarboxylase antizymeIBA 02/2012
1	Estrogen ReceptorsIBA 02/2012
1	Azacitidine (5 Azacytidine)FDA Link 01/2012
1	Histone DemethylasesIBA 01/2012
1	Antineoplastic Agents (Antineoplastics)IBA 01/2012
1	MDL 72527IBA 09/2011
1	Protein Isoforms (Isoforms)IBA 01/2011
1	N(1)- ethyl- N- (11)- ((cyclopropyl)methyl)- 4,8- diazaundecane- 1,11- diamineIBA 10/2010
1	Aspartic Acid ProteasesIBA 05/2010

Therapy/Procedure

9	Therapeutics 01/2022 - 06/2009
4	Chemoprevention 01/2018 - 11/2007
3	Drug Therapy (Chemotherapy) 01/2018 - 01/2012
1	Ligation 12/2019